preemasbiotech

PREMAS Biotech is a research organization focusing on development of innovative technologies and products for Drug discovery research.PREMAS offer Research and manufacturing Services focusing on Cloning and expression Protein purification Protocol/process development for protein scale up Novel Vector construction & Cell based Assay Development. Drug Metabolism PREMAS Biotech has launched its suite of recombinant Human Cytochrome P450 Isozymes expressed in Saccharomyces cerevisiae .These Microsomes contain human CYP450 isozyme and human NADPH oxido reductase hence offering significantly higher specific activity and performance.These Isozymes will be expressed in Yeast which means that these recombinant human enzymes mimic their native forms and Ensures biological and pharmacologically active isoforms. PREMAS will be using their Proprietary vectors for optimized expression. Premas Biotech has expressed the major human drug metabolizing enzymes (DMEs) co-expressed along with human NADPH-dependent cytochrome P450 reductase in Saccharomyces cerevisiae (yeast host system). The yeast, S cerevisiae system, enables efficient expression of complex, multi-subunit proteins along with post- translational processing which mimics human system. PREMAS has launched following CYP450 isozymes in the first phase.CYP3A4 along with Human NADPH oxidoreductase and Cytochrome b5. CYP2D6 along with Human NADPH oxidoreductase. CYP2E1 along with Human NADPH oxidoreductase. CYP1A2 along with Human NADPH oxidoreductase. CYP2C9 along with Human NADPH oxidoreductase and Cytochrome b5. CYP2C19 along with Human NADPH oxidoreductase. These Microsomes will be available in user friendly pack sizes at affordable price points.