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Fluocinolone is a steroid that reduces inflammation or swelling.Hydroquinone is a skin bleaching agent.Tretinoin is a form of vitamin A that helps the skin to renew itself more quickly.Fluocinolone, hydroquinone, and tretinoin topical (for use on the skin) is a combination medicine used to treat melasma (dark skin patches) on the face.Fluocinolone, hydroquinone, and tretinoin topical may also be used for purposes not listed in this medication guide.